Feed-Forward Inhibition of CD73 and Upregulation of Adenosine Deaminase Contribute to the Loss of Adenosine Neuromodulation in Postinflammatory Ileitis
Figure 7
Activity of ecto-5′-nucleotidase/CD73 when ATP (a) and ADP (b) were used as substrates of the ectonucleotidase cascade in the LM-MP of the ileum of control and TNBS-injected rats. ATP and ADP (30 μM) were incubated at zero time. Ecto-5′-nucleotidase/CD73 activity was evaluated by quantifying the ratio [Nucleosides] : [Nucleotides]/min. Average results obtained in four experiments; the vertical bars represent the SEM and are shown when they exceed the symbols in size. (one-way ANOVA followed by Dunnett’s modified t-test) represents significant differences as compared to control animals.
