Novel Insights into miRNA in Lung and Heart Inflammatory Diseases
Figure 2
Role of miRNAs in mechanism of fibrosis. The downregulation of miR-200 and -192 (inhibits epithelial-mesenchymal transition, EMT) and miR-29 (prevents the deposition of extracellular matrix, ECM) promotes fibrosis. Further, miR-21 amplifies TGF-β signaling and promotes myofibroblasts phenotype in fibrosis. This is characterized by increased cellular and expression of alpha-smooth muscle actin (α-SMA) and EDA-fibronectin.