Relationship of MMP-14 and TIMP-3 Expression with Macrophage Activation and Human Atherosclerotic Plaque Vulnerability
Figure 4
((a)–(d)) Representative images of immunohistochemical labelling of advanced human carotid artery atherosclerotic plaques, for colocalisation of MMP-14 (a) with arginase-1 (b), with nuclei counterstained with DAPI (blue; (c)). Scale bar in (a) represents 100 μm and is applicable to panels (a)–(d). (e) The percentage of MMP-14 positive FCMs that also stained for arginase-1 was significantly greater compared to only MMP-14 or arginase-1 (; per group; data expressed as ). (f) Correlation of arginase-1 and MMP-14 positive macrophages in human carotid artery atherosclerotic plaques (; ; ).
