Macrophage Trafficking as Key Mediator of Adenine-Induced Kidney Injury

Figure 1

Adenine-enriched food increases the expression of chemokines and macrophages in renal tissue. Protein expression of CCL2 (a), CCL3 (b), CCL4 (c), and CCL5 (d) was measured in kidney lysates of animals that received standard food or adenine-enriched food. Panel (e) shows the gene expression of CCR5 in the same animals. In panel (f) the dot plot of macrophage infiltration is shown, observed by the CD11b marker. ^∗𝑃<0.05 versus control and ^∗∗𝑃<0.01 versus control.

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