Macrophage Trafficking as Key Mediator of Adenine-Induced Kidney Injury

Figure 3

Macrophage depletion leads to protection in adenine-induced TIN. (a) Renal function of control, adenine, and adenine + clodronate mice was evaluated by serum creatinine (^∗𝑃<0.05 versus control and adenine + clodronate). The inflammatory profile from these animals was measured and indicated by the levels of TNF-α and IL-6 (panels (b) and (c), resp., ^∗𝑃<0.05 versus adenine). Also, fibrosis was assessed by the picrosirius staining (panel (d), ^∗𝑃<0.05 versus control and adenine + clodronate and ^∗∗𝑃<0.05 versus control). (e) Protein expression of p-IKK in control, adenine, and clodronate treated animals.

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