Can the TLR-4-Mediated Signaling Pathway Be “A Key Inflammatory Promoter for Sporadic TAA”?

Table 5

Comparison of systemic inflammatory mediator’s levels “AASSP” from controls bearing combined risk genotype versus controls with other genotypes and between controls bearing +896A TLR4 allele versus controls with +896G TLR4 allele.

Systemic mediators examined	Controls with combined risk genotype; (𝑁=10)	Controls with other genotypes; (𝑁=118)	𝑃 values*
IL-6 (pg/mL)	8.66±2.1	1.1±0.69	<0.0001
TNF-𝛼 (pg/mL)	10.78±1.2	2.1±1.2	<0.0001
CRP (mg/L)	6.13±1.7	0.9±1.5	<0.0001
MMP-2 (ng/mL)	18.8±3.9	2.54±1.3	<0.0001
MMP-9 (ng/mL)	12.7±2.7	1.7±1.6	<0.0001
Systemic mediators examined	Controls with +896ATLR4 allele; (𝑁=10)	Controls with +896G TLR4 allele; (𝑁=118)	𝑃 values*
IL-6 (pg/mL)	5.1±0.9	0.9±0.5	<0.0001
TNF-𝛼 (pg/mL)	7.1±0.6	2.1±1.2	<0.001
CRP (mg/L)	4.3±1.1	0.3±1.9	<0.0001
MMP-2 (ng/mL)	10.6±1.8	1.8±0.9	<0.0001
MMP-9 (ng/mL)	8.3±0.7	0.98±1.5	<0.0001

∗By unpaired 𝑡-test with Welch correction.