Inhibiting C-Reactive Protein for the Treatment of Cardiovascular Disease: Promising Evidence from Rodent Models
Figure 1
ASO-mediated lowering of CRP in rats subjected to LADCA ligation. (a) Serum CRP values determined by ELISA for rats injected i.p. with a CRP targeting ASO (ISIS 197178; 150 mg/kg/wk, ) (■), a control ASO (ISIS 141923; 150 mg/kg/wk, ) (□), or an equivalent volume of 0.9% saline (vehicle, rats) (○). The arrow indicates the day LADCA ligation surgery was performed. The single asterisks and “ns” above the curves indicate or not significant , respectively, for ANOVAs comparing the three treatment groups on each day. The double asterisks below the lines indicate for protected least-squares difference tests comparing the ISIS 197178 treated group to both other groups. (b) Serum IL-6 determined by ELISA for the rats shown in (a). (c) Serum alanine transaminase (ALT) levels determined by ELISA on day 35.
