Obesity and Low-Grade Inflammation Increase Plasma Follistatin-Like 3 in Humans

Figure 2

Plasma follistatin-like 3 in response to an LPS bolus and infusion of TNF-α and IL-6. (a) Effect of intravenous lipopolysaccharide (LPS) bolus (0.3 ng/kg) on circulating fstl3 in healthy subjects (𝑛=12) and patients with type 2 diabetes (𝑛=11) at prior to and 2, 4, 6, and 8 hours following the LPS bolus. No difference between the two groups existed, but a significant time effect. Data is presented as mean ± SEM. *** indicates a time effect 𝑃<0.001, two-way ANOVA. (b) Effect of TNF-α infusion (700 ng/m²⋅h⁻¹) on plasma fstl3. Two-way ANOVA: time 𝑃<0.001, group 𝑃=0.0012 and time *group 𝑃<0.001. 2B. Data is presented as mean ± SEM (𝑛=8). ^#Significantly different from albumin infusion 𝑃<0.01. ^##𝑃<0.001. (c) The effect of IL-6 infusion (5 ug/h) on plasma fstl3. Data is presented as mean ± SEM (𝑛=6 ). ***Significantly different from time points 0.5, 1, 2, 3, and 6 hours, one-way ANOVA.

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