A Natural Flavonoid Glucoside, Icariin, Regulates Th17 and Alleviates Rheumatoid Arthritis in a Murine Model

Figure 7

STAT3 inhibitor suppresses IL-17 production in mice with CIA. (a) Arthritis score and incidence of arthritis in mice with CIA following treatment with STAT3 inhibitor or control. (b) Levels of circulating IgG2a in the serum of mice with CIA. (c) Flow cytometry analysis of the synovial CD4⁺IL-17⁺ T cell subset in mice with CIA. (d) Samples of spleen tissue from mice treated with STAT3 inhibitor or control were stained for CD4⁺IL-17⁺ T cells. versus all other groups, .

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