Roles of 5-Lipoxygenase and Cysteinyl-Leukotriene Type 1 Receptors in the Hematological Response to Allergen Challenge and Its Prevention by Diethylcarbamazine in a Murine Model of Asthma

Figure 6

Montelukast blocks the effects of allergen challenge on wild-type bone-marrow but has no effect on 5-LO-deficient bone-marrow. PAS and ALOX mice sensitized to OVA were pretreated with vehicle (VEIC, 2% DMSO/PBS 1x) or montelukast (MKT, 10 mg/Kg), by intragastric administration (500 μL), 1 h before challenge by aerosol. Bone-marrow was collected 24 h after challenge. Data (mean + SEM; PAS, /11/12; ALOX, /11/12) are the number of EPO+ cells in freshly collected femoral bone-marrow after aerosol challenge. All significant differences are indicated.