Interleukin-33 and Inflammatory Bowel Diseases: Lessons from Human Studies

Figure 2

Representation of IL-33 pathway in T-helper cells. IL-33 interacts with ST2L and the receptor accessory protein IL-RAcP in the membrane. Both possess a domain TIR that allows interacting with MyD88, IRAK1/4, TRAF6, and TAK1 in the cytosol. These intracellular signaling molecules determine IκK inactivation by phosphorylation and degradation in proteasome complex. The consequent NFκB activation results in the production of Th2 cytokines.