Adipose-Derived Stem Cells Ameliorate Allergic Airway Inflammation by Inducing Regulatory T Cells in a Mouse Model of Asthma
Figure 7
Schematic presentation of plausible mechanisms by which ASCs regulate the allergic airway diseases. ASCs migrated to the lung by intravenous administration secrete a variety of soluble factors including IDO, TGF-β, and PGE2. Through a soluble factor or direct contact of ASCs with T lymphocytes, ASCs initiate the expansion of Tregs. Tregs secrete IL-10 and TGF-β which ultimately lead to decrease of lung eosinophil infiltration, as well as allergy-specific Th2 cytokines and Ig production.
