Insulin-Like Growth Factor-I Induces Arginase Activity in Leishmania amazonensis Amastigote-Infected Macrophages through a Cytokine-Independent Mechanism
Figure 2
Effect of IGF-I on cytokine production by BALB/c peritoneal macrophages infected with amastigotes or promastigotes of L. (L.) amazonensis. Cytokine levels were determined in the culture supernatant by ELISA: IFN-γ: (a) and (b); IL1-β: (c) and (d); IL-6: (e) and (f); TGF-β: (g) and (h); TNF: (i) and (j). Boxes represent the median values and the 25th and 75th percentiles (3 experiments, ). Mϕ = macrophage, ama = amastigote, pro = promastigote and Syst = System. compared with promastigote-infected macrophage without IGF-I stimulation. (Kruskal-Wallis test with the Student Newman-Keuls contrast post-test).
