Importins and Exportins Regulating Allergic Immune Responses

Table 2

Specificity of different classes of importins/exportins in transporting cargo to and from the nucleus.

Transporters	Organism	Cells/Tissue	Cargo (proteins) specific to each importin or exportin	Reference
Importin α1	Human	ROS 17/2.8, UMR-106, MC3T3-E1, and SaOS-2	Type 1 parathyroid hormone receptor	[62]
Importin α2	Human	HuT-78 cells	GATA-3	[63]
Importin α3	Human	A5A9 lung cells, human Bronchial smooth muscle cells	NF-κB p50/p65	[25, 50]
Importin α3	Mouse	Mouse lung tissue	NF-κB p65	[11]
Importin α4	Human	A5A9 lung cells	NF-κB p50/p65	[25]
Importin α5	Human	COS-1; HepG2; HuH7 hepatoma cells	STAT3; STAT1-STAT2	[45]; [43]
Importin β1	Human	HEK293; HUVEC; C58; CO57; HeLa	PRPF31; NF-κB; CREB; PTHrP; SRY/SOX-9; Cyclin B1; NFAT	[64–69]; [33]; [68]
Importin β1	Mouse	Sf9	NFAT	[69]
Importin β2	Human	HeLa	HPV16E6 oncoprotein	[70]
Importin β3	Human	HeLa	c-Jun; Ribosomal proteins	[71, 72]
Importin 4	Human	HeLa	Vitamin D receptor; HIF1-α	[73, 74]
Importin 5	Human	HeLa	c-Jun	[70]
Importin 7	Human	HeLa	c-Jun; Histone H1; CREB; SMAD3; Glucocorticoid receptor	[71]; [75, 76]; [33]; [48]; [55]
Importin 8	Human	HaCaT; COS-1	SMADs; Signal recognition particle protein 19	[76, 77]
Importin 9	Human	HeLa	c-Jun; PP2A (PR65)	[71]; [78]
Importin 11	Human	BHK	L12; UbcM2	[79, 80]
Importin 13	Human	HeLa; Airway epithelial cells	c-Jun; Glucocorticoid receptor	[71] [57]
Importin α/β	Human	HTC; MCF-7	HIV-1 integrase; P53	[81, 82]
Exportin 1	Human	NIH-3H3; HeLa	Cyclin D1; IκB; NFAT	[14, 26, 83, 84]
Exportin 4	Mouse	HeLa	elF-5A	[15]
Exportin 5	Human	BHK	Staufen2	[85]
Exportin 6	Human		Actin	[86]
Exportin 7	Human	HeLa; BHK	P50RhoGAP	[87]
Exportin t	Human	HeLa	tRNA	[72, 88]