Deregulation of Annexin-A1 and Galectin-1 Expression in Precancerous Gastric Lesions: Intestinal Metaplasia and Gastric Ulcer

Figure 2

Expression of annexin-A1 protein in gastric mucosa (a–c). (a) Expression of AnxA1 in normal mucosa (C), predominantly in the cytoplasm of epithelial cells (curved arrow) and stroma (arrowhead). (b) Increased expression after intestinal metaplasia (IM) in the nucleus (arrow), cytoplasm (curved arrow), and stromal region (arrowhead). (c) Higher AnxA1 expression can be observed in peripheral area of gastric ulcer (GU) especially in stroma (arrowhead) and epithelial cells (curved arrow and arrow). (d) Absence of immunoreactivity in the reaction control. Asterisk: goblet cell. Hematoxylin of Harris counterstain. Bar: 20 μm. (e) Densitometry analyses (mean ± SE). ^∗𝑃 in relation to C (^∗𝑃<0.05; ^∗∗𝑃<0.01; ^∗∗∗𝑃<0.001); ⁺𝑃<0.05 in relation to IM. a.u.: arbitrary unit.

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