Research Article

Consequences of the Lack of CD73 and Prostatic Acid Phosphatase in the Lymphoid Organs

Table 1

Expression profiles of CD73 and PAP at the mRNA level in different lymphoid tissues*.

CD73 (Nt5e)PAP (Acpp)

Thymus T cells** T cells**
CD4 single positiveiNKT precursors**
Double negative thymocytes
CD8 single positive, mature
iNKT*** precursors**

Lymph nodesCD4 memoryCD8 naïve
CD8 naïve
CD8 memory
Treg
Blood endothelial cells

SpleenGerminal center B cellsCD4 naïve
Memory B cellsCD4 memory
T cells** T cells**
CD4 naïveCD8 naïve
CD4 memoryCD8 memory
CD8 naïveiNKT cells
CD8 memory
Treg
iNKT cells
NK cells**

*The data has been collected from the Immunological Genome Project (http://www.immgen.org/databrowser). The cell types with an expression value (EV) >120 for a given gene are listed (95% confidence of positive expression).
**Only in selected subpopulations.
***iNKT = invariant natural killer T cells.