Silence of NLRP3 Suppresses Atherosclerosis and Stabilizes Plaques in Apolipoprotein E-Deficient Mice

<table>Efficiency of lentivirus transfection. (a) NLRP3 interference downregulated NLRP3 mRNA expression by 64.3% compared with the control via real-time PCR analyses. (b) Caspase-1 activity in protein extracted from aortas was reduced by 56% after NLRP3 silencing, compared with the control. (c and d) Silence of NLRP3 decreased the downstream proinflammatory factors, IL-1<i>β</i> and IL-18, using ELISA. <svg height="17.825001" id="M8" style="vertical-align:-3.13504pt" version="1.1" viewbox="0 0 69.150002 17.825001" width="69.150002" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> versus control. Values are mean ± SD.</table>

Mediators of Inflammation

fig1

Figure 1

Figure 1: Silence of NLRP3 Suppresses Atherosclerosis and Stabilizes Plaques in Apolipoprotein E-Deficient Mice 