Silence of NLRP3 Suppresses Atherosclerosis and Stabilizes Plaques in Apolipoprotein E-Deficient Mice

<table>P4H<i>α</i>1, MMP-2, and MMP-9 mRNA levels in aortas of ApoE-deficient mice were determined with real-time PCR. The mRNA expression of P4H<i>α</i>1 was markedly higher in the NRLP3i group than in the control group, and the mRNA expression levels of MMP-2 and MMP-9 were significantly lower in the treatment group than the control group. <svg height="17.825001" id="M18" style="vertical-align:-3.13504pt" version="1.1" viewbox="0 0 69.150002 17.825001" width="69.150002" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> versus control. Values are mean ± SD.</table>

Mediators of Inflammation

fig4

Figure 4

Figure 4: Silence of NLRP3 Suppresses Atherosclerosis and Stabilizes Plaques in Apolipoprotein E-Deficient Mice 