The Relationship between the Antitumor Effect of the IL-12 Gene Therapy and the Expression of Th1 Cytokines in an HPV16-Positive Murine Tumor Model
Figure 4
Intratumoral expression levels of CD4 and CD8 mRNA. Tumor-bearing mice were treated with the IL-12 gene expression plasmid (asterisks), pcDNA3 plasmid (triangle), PBS (square), or no treatment as control (diamond). Every three days following treatment the mice were sacrificed and by real time RT-PCR the CD4 and CD8 mRNA were detected. The CD8 mRNA level expression was higher than the CD4, however, not significant were detected. Results represent the means ± S.E. values of in each 5-mouse group, .
