Research Article
Elevated OPN, IP-10, and Neutrophilia in Loop-Mediated Isothermal Amplification Confirmed Tuberculosis Patients
Table 2
Comparison of cellular and humoral immunity biomarkers between HC and TB individuals.
| | Biomarker | HC | TB | | | (pg/mL) | Median (range) |
| | General activation | | | | | IL-1 | 0 (0–51.7) | 6.8 (0–40.7) | ** | | IL-1RA | 39.7 (0–374.9) | 34.7 (0–230.9) | ns | | TNF-α | 4.2 (0–15.2) | 9.6 (0–60.5) | **** | | IFN-α | 40.6 (0–128.5) | 23.6 (3.9–157.9) | ns | | IL-6 | 0 (0–23.4) | 6.6 (0–41.4) | **** | | Th1 related | | | | | IFN- | 9.3 (0–35.2) | 12.7 (0–60.8) | ns | | IL-12p40 | 31.4 (0–140.6) | 14 (0–249) | ns | | IL-12p70 | 13.5 (0–73.9) | 6.7 (0–58.2) | ns | | Bone marrow derived | | | | | IL-7 | 11 (0–34.9) | 9.6 (0–25.4) | ns | | GM-CSF | 7.6 (0.8–23.0) | 5.1 (0–49.2) | ns | | G-CSF | 144.1 (19.3–458.0) | 129.4 (0–310.4) | ns | | Stromal, angiogenic | | | | | VEGF | 128 (0–344.1) | 178.4 (0–1287.3) | ns | | EGF | 109.8 (42.3–488.2) | 109.8 (0–459.5) | ns | | Chemokine | | | | | IL-8 | 2.3 (0–10) | 8 (0–61.1) | **** | | IP-10 | 242.6 (97.8–453.3) | 1290 (0–9235) | **** | | MCP-1 | 87.1 (48.7–154.5) | 128.5 (41.6–280.5) | **** | | MIP-1 | 31.9 (0–51.9) | 33.3 (0–58.8) | ns | | Eotaxin | 38.5 (18.1–112.6) | 48 (20.7–133.8) | * | | Matricellular protein | | | | | OPN (ng/mL) | 69 (40–118.9) | 159 (28.9–256) | **** | | Gal-9 | 195.8 (108–507.6) | 377 (0–2181) | **** | | Antibody | | | | | Anti-TBGL IgG (U/mL) | 2.3 (0.5–37.3) | 9.3 (0–64.2) | ** | | Anti-TBGL IgA (U/mL) | 1 (0.2–76) | 2.6 (0–57.6) | * |
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, , , , ns: not significant.
TB group versus HC group by Mann-Whitney -test.
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