Production of the Growth Factors GM-CSF, G-CSF, and VEGF by Human Peripheral Blood Cells Induced with Metal Complexes of Human Serum γ-Globulin Formed with Copper or Zinc Ions

Figure 2

Production of G-CSF by normal human PBC induced with human serum γ-globulin metal complexes formed with copper or zinc ions, with control γ-globulins, and with copper and zinc ions used alone (𝑀±𝑚, 𝑛=8). Induction for 48 hrs at 37°C. In the ordinate axis: concentration of G-CSF, pg/ml. ^∗𝑃<0.1 compared with γ-globulin complex formed with zinc ions (2); ^∗∗𝑃<0.01 compared with zinc ions used alone (3); ^∗∗∗𝑃<0.001 compared with zinc ions used alone (3) or with control γ-globulin for the zinc complex (1), as well as compared with copper ions used alone (6) or with control γ-globulin for the copper complex (4) and with copper ions used alone (6).