Cardiac Fibroblasts Aggravate Viral Myocarditis: Cell Specific Coxsackievirus B3 Replication

Figure 1

Increased cardiac inflammation in mice 7 days after CVB3 infection. (a) Hematoxylin/eosin staining of cardiac tissue from CVB3 infected B6 mice revealed a clear number of invaded inflammatory cells. (b) Virus load in cardiac tissue 7 days after CVB3 infection. ((c)–(h)) Gene expression analyses of various cytokines in cardiac tissue of healthy (white bar) and CVB3 infected (grey bar) B6 mice. Data were plotted as mean ± SEM as x-fold to the house keeping gene CDKN1b. Significantly different versus noninfected mice (control); ; ; n.d.: not detectable.

(a)

(b)

(c)

(d)

(e)

(f)

(g)

(h)