Ticlopidine in Its Prodrug Form Is a Selective Inhibitor of Human NTPDase1
Figure 3
Comparative effect of ticlopidine on recombinant murine NTPDase1. ATPase and ADPase activity of mouse (a) or rat (b) NTPDase1 without and with either 100 μM or 1 mM ticlopidine are presented. The 100% activity with ATP as the substrate in the absence of ticlopidine was and nmol min−1 for mouse and rat NTPDase1, respectively, and with ADP and nmol min−1 for mouse and rat NTPDase1, respectively. Data are presented as the mean ± SD of 3 experiments carried out in triplicate. ; .