Research Article

Ticlopidine in Its Prodrug Form Is a Selective Inhibitor of Human NTPDase1

Figure 3

Comparative effect of ticlopidine on recombinant murine NTPDase1. ATPase and ADPase activity of mouse (a) or rat (b) NTPDase1 without and with either 100 μM or 1 mM ticlopidine are presented. The 100% activity with ATP as the substrate in the absence of ticlopidine was and  nmol min−1 for mouse and rat NTPDase1, respectively, and with ADP and  nmol min−1 for mouse and rat NTPDase1, respectively. Data are presented as the mean ± SD of 3 experiments carried out in triplicate. ; .
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(a) Mouse NTPDase1
547480.fig.003b
(b) Rat NTPDase1