Inflammatory Lung Disease in Rett Syndrome

Table 7

Relationships between lung ventilation/perfusion (𝑉/𝑄) patterns and the redox/antioxidant status in patients with typical Rett syndrome (𝑛=228).

Redox and antioxidant markers	Pulmonary ventilation/perfusion (𝑉/𝑄) patterns in typical Rett syndrome					𝑃 value; (ANOVA)
	No mismatch; (𝑁=44)	“Low”; (𝑁=64)	“High”; (𝑁=73)	“Mixed”; (𝑁=36)	“Simple” mismatch; (𝑁=11)
P-NPBI (nmol/mL)	𝟎.𝟓𝟎±𝟎.𝟑𝟐^𝐚	𝟎.𝟖𝟔±𝟎.𝟎𝟕^𝐚,𝐛,𝐜	𝟎.𝟗𝟏±𝟎.𝟏𝟓^𝐚	𝟏.𝟎𝟐±𝟎.𝟐𝟐^𝐚,𝐛,𝐜	𝟎.𝟕𝟏±𝟎.𝟎𝟓^𝐛,𝐜	<0.001
IE-NPBI (nmol/mL)	𝟎.𝟖𝟎±𝟎.𝟐𝟒^𝐚	𝟏.𝟎𝟒±𝟎.𝟎𝟓^𝐚,𝐛	𝟏.𝟐𝟎±𝟎.𝟐𝟏^𝐚,𝐛	𝟏.𝟑𝟎±𝟎.𝟒𝟗^𝐚,𝐛	𝟎.𝟗𝟔±𝟎.𝟏𝟑^𝐛	<0.001
F2-IsoPs (pg/mL)	𝟐𝟕.𝟑±𝟏𝟏.𝟏^𝐚	𝟔𝟓.𝟐±𝟏𝟒.𝟒^𝐚,𝐛	𝟕𝟔.𝟓±𝟏𝟑.𝟐^𝐚,𝐛	𝟏𝟎𝟎.𝟖±𝟏𝟏.𝟒^𝐚,𝐛	𝟒𝟔.𝟐±𝟕.𝟗^𝐛	<0.001
GSH (𝜇mol/L )	𝟏𝟐𝟎𝟔±𝟏𝟒𝟎^𝐚	𝟏𝟖𝟔𝟕±𝟕𝟓𝟗^𝐚,𝐛	𝟏𝟕𝟗𝟒±𝟓𝟎𝟕^𝐚,𝐛	𝟏𝟒𝟒𝟐±𝟑𝟕𝟑^𝐚,𝐛	𝟏𝟒𝟏𝟗±𝟓𝟐𝟑^𝐛	<0.001
GSSG (𝜇mol/L )	𝟖.𝟎±𝟑.𝟒^𝐚	𝟏𝟗𝟑.𝟔±𝟖𝟓.𝟑^𝐚,𝐛	𝟐𝟐𝟐.𝟓±𝟔𝟏.𝟓^𝐚,𝐛	𝟏𝟑𝟐.𝟎±𝟐𝟓.𝟗^𝐚	𝟏𝟒𝟒.𝟑±𝟕𝟏.𝟒^𝐛	<0.001
GSH/GSSG ratio	𝟏𝟕𝟓±𝟖𝟑^𝐚	𝟏𝟐.𝟐±𝟕.𝟖^𝐚	𝟖.𝟐±𝟏.𝟗^𝐚	𝟏𝟏.𝟔±𝟓.𝟏^𝐚	𝟏𝟏.𝟏±𝟓.𝟐^𝐚	<0.001

Data are expressed as means ± SD. Bold characters indicate statistical significant differences; superscript letters indicate significant pairwise post hoc differences; P-NPBI: plasma non-protein-bound iron; IE-NPBI: intraerythrocyte non-protein-bound iron; F₂-IsoPs: plasma F₂-isoprostanes; GSH: reduced glutathione; GSSG: oxidized glutathione.