Changes in Cerebrospinal Fluid Biomarkers in Human Herpesvirus-6-Associated Acute Encephalopathy/Febrile Seizures
Table 2
Descriptive statistics for the biomarkers examineda.
Biomarkers
Controls
HHV-6 complex FS
HHV-6 encephalopathy
Global
Controls versus HHV-6 FS
Controls versus HHV-6 encephalopathy
HHV-6 FS versus HHV-6 encephalopathy
8-OHdG, ng/mL
0.063 (0.01)
0.116 (0.061)
0.129 (0.07)
0.0025
<0.05
<0.01
ns
HEL, nmol/L
3.62 (1.08)
5.24 (3.63)
3.59 (1.87)
0.1863
ns
ns
ns
Tau, pg/mL
609.0 (342.0)
654.7 (213.7)
13,905.6 (14,201.1)
0.0028
ns
<0.05
ns
IL-6, pg/mL
3.2 (3.0)
5.8 (5.3)
74.6 (116.9)
0.0349
ns
<0.01
ns
IL-10, pg/mL
0.4 (0.3)
0.6 (0.8)
1.4 (2.1)
0.1663
ns
ns
ns
TNF-, pg/mL
0.1 (0.1)
0.3 (0.5)
3.4 (4.0)
0.0036
ns
<0.01
<0.05
8-OHdG: 8-hydroxy-2′-deoxyguanosine; HEL: hexanoyl-lysine adduct; HHV-6: human herpesvirus-6; FS: febrile seizure; ns: not significant; IL: interleukin; TNF: tumor necrosis factor.
aValues are expressed as the mean (standard deviation).
