Aspirin Modulates Innate Inflammatory Response and Inhibits the Entry of Trypanosoma cruzi in Mouse Peritoneal Macrophages
Figure 2
The effect of ASA on the entry of T. cruzi into macrophages was prevented by Boc-2. (a) Internalization index of the interaction process between macrophages treated for 30 minutes separately either with or without drugs (0.625 μM ASA or 100 μM Boc-2). Results are the mean ± standard error for triplicate determinations and are representative of two independent experiments. , for a comparison with infected cells cultured in medium alone. , for a comparison with infected cell treated with ASA. (b) PGE2 restores aspirin effect on T. cruzi entry into macrophages. Macrophages were treated for 30 minutes separately either with or without PGE2 (35.2, 3.52, or 0.35 ng mL−1) alone or in combination (ASA 0.625 mM + PGE2 3.52 ng mL−1). Results are the mean ± standard error and are representative of two independent experiments. for a comparison with infected cells cultured in medium alone. for comparison with infected cell treated with ASA or PGE2 alone. for a comparison with infected cells cultured in medium alone.
