Immunoregulatory Effects of Bone Marrow-Derived Mesenchymal Stem Cells in the Nasal Polyp Microenvironment
Figure 3
Bone marrow-derived mesenchymal stem cells modulating the polyp microenvironment in vitro. (a) NK cell (NK1.1+) frequency alone and in coculture with MSCs; (b) CD4+ and CD8+ frequencies alone and in coculture with MSCs; (c) CD8+ and CD69+ frequencies alone and in coculture with MSCs; (d) CD4+ and CD69+ frequencies alone and in coculture with MSCs; (e) B cell (CD19+) frequency alone and in coculture with MSCs; (f) CD11c+ and CD11c+CD40+ dendritic cell frequencies alone and in coculture with MSCs and CD14+ and CD14+CD40+ monocyte frequencies alone and in coculture with MSCs. The presence of MSCs may immunomodulate the phenotype of polyp-derived cells toward an immunosuppressive profile.
