Immunoregulatory Effects of Bone Marrow-Derived Mesenchymal Stem Cells in the Nasal Polyp Microenvironment
Figure 4
Bone marrow-derived mesenchymal stem cells exhibit functional immunosuppressive action on polyp-derived cells in vitro. (a, b) Proliferative index of CD4+ and CD8+ cells, respectively, stimulated with phytohemagglutinin (PHA), in the presence or absence of MSCs; (c) frequency of CD4+CD25+Fpxp3+ cells in the presence or absence of MSCs. Functionally, MSCs exhibited immunosuppressive action on polyp-derived cells, as represented by inhibition of proliferation of CD4+ and CD8+ cells with a concomitant increase in CD4+CD25+Fpxp3+ frequency.
