Hantaan Virus Infection Induces CXCL10 Expression through TLR3, RIG-I, and MDA-5 Pathways Correlated with the Disease Severity
Figure 1
Increased CXCL10 level in HFRS patients’ sera is positively correlated with HFRS severity. (a) Box plot displaying the minimum, 25th, 50th, 75th, and maximum percentiles of CXCL10 levels. Comparison of serum CXCL10 contents between healthy donors (NC) and HFRS patients. Data were means ± SE (NC, ; HFRS, ). ***, HFRS patients versus healthy donors. (b) Contents of CXCL10 in acute and convalescent phases in HFRS patients. Data were means ± SE (NC, ; HFRS, ). ***, acute or convalescent phase versus NC. (c) Serum CXCL10 levels were positively correlated with blood urea nitrogen (BUN), creatinine (Crea), and white blood cells (WBC) in the entire group of subjects while negatively correlated with platelet count (PLT). The and values were indicated in the graphs. (d) Serum CXCL10 levels were in relation to the plasma viral loads. Patients with viral loads >1500 copies/mL had significant higher CXCL10 levels than those with viral loads <1500 copies/mL (***).
