Research Article

Hantaan Virus Infection Induces CXCL10 Expression through TLR3, RIG-I, and MDA-5 Pathways Correlated with the Disease Severity

Figure 2

The expression level of CXCR3 increases highly in acute phase of HFRS. (a) The levels of CXCR3 expression on CD14+ subsets in PBMCs were measured by flow cytometry. The CD14+ cells were gated. The expressions of CXCR3 on CD14 population were presented from a healthy donor (NC), a HFRS patient suffering firstly from acute phase, and then from the convalescent phase, respectively. Shaded histograms represented the isotype controls; black lines represented the expression of CXCR3 on CD14 gated PBMCs. The percentage of CXCR3+ cells in the CD14+ subsets was indicated in each graph. (b) The percentages of CD14+CXCR3+ cells in all the CD14+ subsets in PBMCs were shown in different groups. Values that are statistically different ( ) between NC and acute phase or between acute phase and convalescent phase are indicated (***).
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(a)
697837.fig.002b
(b)