New Insight for the Diagnosis of Gastrointestinal Acute Graft-versus-Host Disease
Figure 3
Probe-based confocal laser endomicroscopy (pCLE) patterns observed in GI-GVHD patients following intravenous injection of fluorescein. (a) Normal sigmoid, (b) abnormal microvessel network with dilation of a microvessel surrounding a colonic crypt (mild GVHD), (c) mild increase in fluorescein intensity in the lamina propria (mild GVHD), (d) distorted crypts (moderate GVHD), and ((e), (f)) major architectural changes showing proliferation and dilation of microvessels in the lamina propria, major fluorescein extravasation, and complete destruction of the colonic crypt architecture (severe GVHD).
