Korean Red Ginseng Saponin Fraction Rich in Ginsenoside-Rb1, Rc and Rb2 Attenuates the Severity of Mouse Collagen-Induced Arthritis

Figure 7

Effect of RGSF-A on cytokine production profile in cultured and anti-CII peptide stimulated splenocytes isolated from CIA mice. Splenocytes from naïve, RGSF-A, MTX, or vehicle-treated mice isolated, cultured, and collagen peptide stimulated followed by analysis of cytokine levels in the supernatant as indicated in the materials and methods section. Treatment of RGSF-A at higher dose reduced CIA IL-17 (a) and IL-6 (b) secretions but induced IL-10 production in splenocytes from CIA mice cultured with anti-CII peptide. ^∗𝑃<0.05, ^∗∗𝑃<0.01, and ^∗∗∗𝑃<0.001 as compared with vehicle treatment; 𝑛=6 for each group.

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(b)

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