Early Effects of a Hypocaloric, Mediterranean Diet on Laboratory Parameters in Obese Individuals
Table 2
Comparison of demographic, anthropometric, clinical, and biochemical features of obese patients at baseline and during follow-up.
Baseline
1 month
4 months
Weight (Kg)
91 (82–112)
87 (83–101)
87 (78–98)
<0.001
BMI (Kg/m2)
37 (32–39)
36 (31–38)
35 (31–38)
<0.001
Total cholesterol (mg/dL)
199 (172–225)
190 (151–222)
209 (168–218)
0.249
HDL (mg/dL)
50 (38–57)
44 (39–53)
49 (41–57)
0.073
LDL (mg/dL)
131 (95.0–160.0)
117 (95.0–153.0)
120 (95.0–149)
0.444
Triglycerides (mg/dL)
105 (66–169)
111 (76–132)
95 (83–149)
0.420
Fasting glucose (mg/dL)
97 (91–107)
96 (91–99)
94 (87–104)
0.168
Basal insulin (U/mL)
18.0 (13.0–27.0)
15.0 (10.0–20.0)
14.0 (10.0–28.0)
0.037
HOMA-IR
4.0 (3.0–6.0)
4.0 (2.0–5.0)
3.0 (3.0–6.0)
0.026
GT (U/L)
22.0 (15.0–44.0)
21.0 (14.0–40.0)
19.0 (13.0–65.0)
0.299
AST (U/L)
23.0 (17.0–27.0)
21.0 (18.0–24.0)
19.0 (16.0–24.0)
0.238
ALT (U/L)
27.0 (19.0–34.0)
25.0 (18.0–35.0)
22.0 (17.0–33.0)
0.220
LDH (U/L)
345 (326–397)
350.0 (329–403)
323 (296–376)
0.023
Adiponectin (g/mL)
5.0 (3.0–7.0)
4.0 (3.0–6.0)
5.0 (3.0–7.0)
0.923
Leptin (ng/mL)
47.0 (31.0–70.0)
35.0 (22.0–46.0)
36.0 (27.0–44.0)
0.008
Resistin (ng/mL)
5.0 (4.0–6.0)
5.0 (5.0–7.0)
5.0 (4.0–7.0)
0.267
Visfatin (ng/mL)
7.0 (5.0–8.0)
7.0 (6.0–9.0)
7.0 (6.0–9.0)
0.559
Cystatin C (mg/dL)
0.79 (0.71–0.85)
0.78 (0.67–0.85)
0.78 (0.72–0.85)
0.640
PT (%)
102 (98–104)
103 (96–104)
104 (99–110)
0.211
aPTT (sec)
27 (26–28)
28 (27–30)
27 (25–29)
0.001
Fibrinogen (mg/dL)
325 (274–369)
324 (287–349)
308 (260–341)
0.676
PAI-1 (U/mL)
5.0 (2.0–6.0)
3.0 (1.0–6.0)
3.0 (1.0–4.0)
0.610
hsCRP (mg/dL)
2.8 (1.8–7.0)
2.8 (1.61–5.2)
4.0 (1.2–6.4)
0.568
IL-2 (pg/mL)
0.0 (0.0–5.0)
3.0 (0.0–5.0)
3.0 (0.0–6.0)
0.154
IL-4 (pg/mL)
0.0 (0.0–2.0)
0.0 (0.0–2.0)
0.0 (0.0–0.0)
0.409
IL-6 (pg/mL)
1.3 (1.0–2.0)
1.3 (1.0–2.0)
1.0 (1.0–2.0)
0.394
IL-8 (pg/mL)
10.0 (7.0–28.0)
14.0 (6.0–38.0)
14.0 (10.0–25.0)
0.535
IL-10 (pg/mL)
0.0
0.0
0.0
—
VEGF (pg/mL)
193 (98–361)
178 (101–283)
174 (90–267)
0.568
IFN (pg/mL)
2.0 (0.0–4.0)
2.0 (0.0–4.0)
3.0 (0.0–6.0)
0.486
TNF (pg/mL)
3.0 (3.0–5.0)
3.0 (3.0–6.0)
4.0 (3.0–7.0)
0.867
IL-1 (pg/mL)
0.0
0.0
0.0
—
IL-1 (pg/mL)
0.8 ± 2.0*
0.7 ± 2.3*
0.8 ± 2.7*
0.662
MCP-1 (pg/mL)
351 (206–395)
352 (232–515)
367 (214–485)
0.302
EGF (pg/mL)
86 (68–130)
114 (84–144)
97 (68–139)
0.013
Nonparametric Friedman test has been used for comparisons at three times. All variables are expressed as median and quartiles. *These data are expressed as average ± SD.
