Early Effects of a Hypocaloric, Mediterranean Diet on Laboratory Parameters in Obese Individuals
Table 4
Effect of weight loss on biochemical parameters.
Weight loss >5%
Weight loss ≤5%
Beta
Total cholesterol (mg/dL)
206 (184–226)
177 (146–218)
0.338
1.699
0.106
HDL (mg/dL)
52 (44–68)
49 (45–54)
0.075
0.321
0.752
Triglycerides (mg/dL)
89 (79–154)
101 (71–134)
0.020
0.081
0.936
Fasting glucose (mg/dL)
95 (88–119)
94 (86–103)
0.300
1.181
0.252
Basal insulin (U/mL)
10.0 (8.7–15.7)
24.0 (12.0–28.5)
−0.506
−2.430
0.025
HOMA-IR
3.0 (2.0–3.2)
5.0 (3.0–6.0)
−0.435
−2.040
0.056
GT (U/L)
19.5 (14.2–56.0)
17.0 (11.0–81.0)
0.123
0.487
0.632
AST (U/L)
20.5 (15.7–24.2)
18.0 (16.0–24.0)
0.144
0.646
0.526
ALT (U/L)
19.0 (17.2–32.0)
23.0 (14.5–33.5)
0.329
1.317
0.203
LDH (U/L)
323 (298–389)
334 (295–363)
−0.141
−0.587
0.564
Adiponectin (g/mL)
6.0 (4.0–7.25)
4.0 (3.0–5.0)
0.298
1.164
0.259
Leptin (ng/mL)
31.5 (19–40.0)
41.0 (31.5–53.5)
−0.575
−2.478
0.023
Resistin (ng/mL)
5.0 (4.0–8.0)
6.0 (4.0–9.0)
−0.258
−0.940
0.359
Visfatin (ng/mL)
7.5 (6.0–10.0)
7.0 (6.0–8.5)
0.088
0.353
0.729
Cystatin C (mg/dL)
1.0 (1.0-1.0)
1.0 (1.0-1.0)
—
—
—
PT (%)
105 (102–111)
103 (97–108)
0.079
0.321
0.752
aPTT (sec)
27 (25–28)
27 (25–29)
−0.121
−0.554
0.586
Fibrinogen (mg/dL)
297 (261–346)
319 (244–339)
−0.068
−0.271
0.790
PAI-1 (U/mL)
2.5 (1.0–4.5)
3.0 (1.5–4.0)
0.010
0.038
0.970
hsCRP (mg/dL)
4.5 (1.0–9.2)
4.0 (2.0–5.5)
0.014
0.065
0.949
IL-2 (pg/mL)
3.5 (0.0–5.2)
3.0 (0.0–6.0)
0.001
0.002
0.999
IL-4 (pg/mL)
0.0 (0.0–2.0)
0.0 (0.0–2.0)
—
—
—
IL-6 (pg/mL)
1.0 (1.0–2.0)
1.0 (1.0–2.0)
0.058
0.256
0.801
IL-8 (pg/mL)
15.0 (12.5–28.2)
12.0 (9.0–23.0)
0.070
0.298
0.769
IL-10 (pg/mL)
0.0
0.0
—
—
—
VEGF (pg/mL)
230 (69–347)
157 (100–238)
−0.025
−0.105
0.917
IFN (pg/mL)
4.0 (0.7–9.7)
2.0 (0.0–4.0)
0.318
1.159
0.271
TNF (pg/mL)
4.0 (2.7–7.2)
5.0 (4.0–7.5)
−0.191
−0.887
0.386
IL-1 (pg/mL)
0.0
0.0
—
—
—
IL-1 (pg/mL)
1.4 ± 4.2*
0.3 ± 0.7*
—
—
—
MCP-1 (pg/mL)
372 (228–547)
338 (203–444)
0.243
1.111
0.280
EGF (pg/mL)
77 (54.5–106.2)
121 (87–156)
−0.468
−2.273
0.035
Multivariate linear regression analysis has been adjusted for gender and age. All variables are expressed as median and quartiles.*These data are expressed as average ± SD.
