Topical Herbal Application in the Management of Atopic Dermatitis: A Review of Animal Studies

Table 3

Basic characteristics of the animal models used in the included studies.

Study	Sex/model species	Induction of AD-like skin	Barrier disruption	Investigation site
Qi et al. [27]	F/hairless mouse	DNCB	N/A	Dorsal skin
Lee et al. [14]	M/NC/Nga mouse	DfE	SDS	Dorsal skin, ears
Choi et al. [15]	F/NC/Nga mouse	DfE	N/A	Dorsal skin
Sohn et al. [28]	M/BALB/c mouse	DNCB	N/A	Dorsal skin
Wu et al. [29]	M/NC/Nga mouse	DNFB	N/A	Dorsal skin
Yang et al. [16]	F/NC/Nga mouse	DNCB	N/A	Dorsal skin, ears
Sung et al. [30]	M/NC/Nga mouse	DfE	SDS	Dorsal skin, ears
Nam et al. [31]	M/C57BL/6 mouse	DNFB	N/A	Abdominal skin, ears
Choi et al. [24]	F/BALB/c mouse	DNCB, DfE, and skin injury	N/A	Ears
Sung et al. [9]	M/NC/Nga mouse	DfE	SDS	Dorsal skin, ears
Lee et al. [22]	M/NC/Nga mouse	DfE	SDS	Dorsal skin, ears
Ngatu et al. [17]	M/NC/Nga mouse	TNCB	N/A	Abdominal skin, ears
Yang et al. [18]	F/NC/Nga mouse	DNCB	SDS	Dorsal skin, ears
Hwang et al. [25]	F/BALB/c mouse	DNCB, DfE, and skin injury	N/A	Ears
Choi et al. [32]	M/NC/Nga mouse	DNCB	N/A	Dorsal skin, ears
Sung et al. [33]	M/NC/Nga mouse	DNCB and DfE	SDS	Dorsal skin, ears
Kang and Shin [34]	M/NC/Nga mouse	DNCB	N/A	Dorsal skin
Sung et al. [35]	M/NC/Nga mouse	DfE	SDS	Dorsal skin, ears
Park et al. [10]	F/NC/Nga mouse	DNCB	N/A	Dorsal skin, right ear
Yang et al. [36]	M/NC/Nga mouse	DfE	N/A	Dorsal skin, ears
Kim et al. [37]	F/BALB/c mouse	DNCB	SDS	Dorsal skin
Choi et al. [38]	M/NC/Nga mouse	DNCB	N/A	Dorsal skin, ears

DNCB: 1-chloro-2,4-dinitrobenzene, DfE: D. farinae extract, DNFB: 2,4-dinitrofluorobenzene, TNCB: 2,4,6-trinitrochlorobenzene, N/A: not applicable, SDS: sodium dodecyl sulfate, M: male, and F: female.