Review Article
Topical Herbal Application in the Management of Atopic Dermatitis: A Review of Animal Studies
Table 3
Basic characteristics of the animal models used in the included studies.
| Study | Sex/model species | Induction of AD-like skin | Barrier disruption | Investigation site |
| Qi et al. [27] | F/hairless mouse | DNCB | N/A | Dorsal skin | Lee et al. [14] | M/NC/Nga mouse | DfE | SDS | Dorsal skin, ears | Choi et al. [15] | F/NC/Nga mouse | DfE | N/A | Dorsal skin | Sohn et al. [28] | M/BALB/c mouse | DNCB | N/A | Dorsal skin | Wu et al. [29] | M/NC/Nga mouse | DNFB | N/A | Dorsal skin | Yang et al. [16] | F/NC/Nga mouse | DNCB | N/A | Dorsal skin, ears | Sung et al. [30] | M/NC/Nga mouse | DfE | SDS | Dorsal skin, ears | Nam et al. [31] | M/C57BL/6 mouse | DNFB | N/A | Abdominal skin, ears | Choi et al. [24] | F/BALB/c mouse | DNCB, DfE, and skin injury | N/A | Ears | Sung et al. [9] | M/NC/Nga mouse | DfE | SDS | Dorsal skin, ears | Lee et al. [22] | M/NC/Nga mouse | DfE | SDS | Dorsal skin, ears | Ngatu et al. [17] | M/NC/Nga mouse | TNCB | N/A | Abdominal skin, ears | Yang et al. [18] | F/NC/Nga mouse | DNCB | SDS | Dorsal skin, ears | Hwang et al. [25] | F/BALB/c mouse | DNCB, DfE, and skin injury | N/A | Ears | Choi et al. [32] | M/NC/Nga mouse | DNCB | N/A | Dorsal skin, ears | Sung et al. [33] | M/NC/Nga mouse | DNCB and DfE | SDS | Dorsal skin, ears |
Kang and Shin [34] | M/NC/Nga mouse | DNCB | N/A | Dorsal skin | Sung et al. [35] | M/NC/Nga mouse | DfE | SDS | Dorsal skin, ears | Park et al. [10] | F/NC/Nga mouse | DNCB | N/A | Dorsal skin, right ear | Yang et al. [36] | M/NC/Nga mouse | DfE | N/A | Dorsal skin, ears | Kim et al. [37] | F/BALB/c mouse | DNCB | SDS | Dorsal skin | Choi et al. [38] | M/NC/Nga mouse | DNCB | N/A | Dorsal skin, ears |
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DNCB: 1-chloro-2,4-dinitrobenzene, DfE: D. farinae extract, DNFB: 2,4-dinitrofluorobenzene, TNCB: 2,4,6-trinitrochlorobenzene, N/A: not applicable, SDS: sodium dodecyl sulfate, M: male, and F: female.
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