Innate Immunity to Leishmania Infection: Within Phagocytes

Table 1

The role of phagocytes and IL-4 in immunity to L.  major infection.

Phagocytes	Role in immunity	Experimental model	Outcome to infection	Ref.
Monocytes	APCs	Injected in B6 mice 4 wks upon infection	Generation of Mo-DCs/APCs (Th1 responses)	[32]
Monocytes	NO-producing effector cells	Injected in B6 mice upon infection	Resistance to acute infection	[42]
Monocytes	ROS-producing effector cells	B6-CCR2.KO	Susceptibility	[31]
DCs	APCs	B6-CCR2.KO	Susceptibility/Th2 response	[29]
DCs	APCs/NO-producing effector cells	B6-CCR2.KO	Defective recruitment of DCs to LN	[30]
DCs	APCs/NO-producing effector cells	CD11c^creIL-4R𝛼^flox/-	Susceptibility/Th2 response	[39]
Macrophages	NO-producing effector cells	LysM^creIL-4R𝛼^flox/-	Resistance to acute infection	[9]