Mediators of Inflammation

Research Article

Lack of Association between ABO, PPAP2B, ADAMST7, PIK3CG, and EDNRA and Carotid Intima-Media Thickness, Carotid Plaques, and Cardiovascular Disease in Patients with Rheumatoid Arthritis

Table 1

Demographic and clinical characteristics of the Spanish patients with RA included in the study.
Clinical feature% ( )
Patients2140
Main characteristics 
 Age at the time of disease onset (years, mean ± SD)
 Follow-up (years, mean ± SD)
 Percentage of women 75.1
 Rheumatoid factor positive*67.9 ( )
 Anti-CCP antibodies positive 59.2 ( )
 Shared epitope positive 62.4 ( )
 Erosions54.7 ( )
 Extra-articular manifestations**31.5 ( )
Cardiovascular risk factors  
 Hypertension 38.7 ( )
 Diabetes mellitus 12.2 ( )
 Dyslipidemia 37.3 ( )
 Obesity 16.8 ( )
 Smoking habit23.8 ( )
Patients with cardiovascular events17.6 ( )
 Ischemic heart disease8.3 ( )
 Heart failure5.3 ( )
 Cerebrovascular accident5.3 ( )
 Peripheral arteriopathy2.3 ( )
RA: rheumatoid arthritis; SD: standard deviation; Anti-CCP antibodies: anticyclic citrullinated peptide antibodies.
At least two determinations were required for analysis of this result.
Extra-articular manifestations of the disease (if RA patients experienced at least one of the following manifestations: nodular disease, Felty’s syndrome, pulmonary fibrosis, rheumatoid vasculitis, or secondary Sjögren’s syndrome) [4].