Urinary Eicosanoid Metabolites in HIV-Infected Women with Central Obesity Switching to Raltegravir: An Analysis from the Women, Integrase, and Fat Accumulation Trial

<table>Median baseline urinary eicosanoid levels by nucleoside reverse transcriptase inhibitor use. Panel (a) shows F<sub>2</sub>-IsoP; Panel (b) shows PGE-M; Panel (c) shows PGI-M; Panel (d) shows TxB<sub>2</sub>. <svg height="17.825001" id="M29" style="vertical-align:-3.13504pt" version="1.1" viewbox="0 0 21.375 17.825001" width="21.375" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> value = 0.05; <svg height="17.825001" id="M30" style="vertical-align:-3.13504pt" version="1.1" viewbox="0 0 28.362499 17.825001" width="28.362499" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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q-4 71 -28 134q17 33 42 46q24 -12 42 -46q-24 -63 -28 -134q36 23 56.5 41.5t45.5 49.5q36 2 61 -13q0 -28 -19 -59q-65 -10 -130 -43q65 -33 130 -43q19 -31 19 -59z" id="x2217"></path></g><g transform="matrix(.012,-0,0,-.012,9.885,5.525)"><path d="M471 153q-22 -15 -61 -13q-25 31 -45.5 49.5t-56.5 41.5q4 -71 28 -134q-17 -33 -42 -46q-24 12 -42 46q24 63 28 134q-36 -23 -56.5 -41.5t-45.5 -49.5q-36 -2 -61 13q0 28 19 59q65 10 130 43q-65 33 -130 43q-19 31 -19 59q22 15 61 13q25 -31 45.5 -49.5t56.5 -41.5
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<g transform="matrix(.017,-0,0,-.017,17.488,14.875)"><path d="M619 482q0 -69 -40.5 -119t-96 -72.5t-118.5 -26.5h-44l-70 20l-31 -151q-14 -67 0.5 -83t89.5 -22l-5 -28h-287l8 28q65 7 81.5 22t29.5 83l79 398q12 56 0.5 70.5t-78.5 20.5l7 28h255q108 0 164 -43t56 -125zM524 478q0 141 -146 141q-25 0 -47 -8q-16 -6 -20.5 -13.5
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</svg> value = 0.04. Black (x) lines indicate within-group median; grey dashed lines (-) indicate within-group 25th and 75th percentiles. F<sub>2</sub>-IsoPs: F<sub>2</sub>-isoprostanes; PGE-M: prostaglandin E<sub>2</sub> metabolite; PGI-M: prostacyclin metabolite; TxB<sub>2</sub>: thromboxane B<sub>2</sub>. Units are ng/mg creatinine.</table>

Mediators of Inflammation

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Figure 1

Figure 1: Urinary Eicosanoid Metabolites in HIV-Infected Women with Central Obesity Switching to Raltegravir: An Analysis from the Women, Integrase, and Fat Accumulation Trial 

Figure 1 | Urinary Eicosanoid Metabolites in HIV-Infected Women with Central Obesity Switching to Raltegravir: An Analysis from the Women, Integrase, and Fat Accumulation Trial 