Urinary Eicosanoid Metabolites in HIV-Infected Women with Central Obesity Switching to Raltegravir: An Analysis from the Women, Integrase, and Fat Accumulation Trial

Table 3

Multivariate generalized linear models of predictors of 24-week eicosanoid changes.

Covariate	F2-IsoP		PGE-M		PGI-M		TxB2
	𝛽 (95% CI)	𝑃	𝛽 (95% CI)	𝑃	𝛽 (95% CI)	𝑃	𝛽 (95% CI)	𝑃
Study arm; (RAL versus PI/NNRTI)	0.25 (−0.79, 1.30)	0.63	1.6 (−4.5, 7.7)	0.60	0.04 (−0.02, 0.09)	0.19	0.12 (−0.02, 0.26)	0.10
PI use at baseline; (yes versus no)	0.46 (−0.54, 1.46)	0.35	−3.9 (−9.6, 1.8)	0.17	0.004 (−0.05, 0.05)	0.85	0.06 (−0.07, 0.20)	0.35
Age ≥ 50 years; (versus <50)	0.73 (−0.66, 2.12)	0.29	8.3 (0.3, 16.3)	0.04	0.02 (−0.06, 0.10)	0.59	−0.02 (−0.21, 0.17)	0.81
Current smoking; (yes versus no)	−0.37 (−1.54, 0.81)	0.53	0.9 (−6.0, 7.9)	0.78	−0.01 (−0.07, 0.05)	0.69	0.11 (−0.05, 0.27)	0.18
Baseline BMI	0.02 (−0.06, 0.09)	0.63	0.3 (−0.1, 0.7)	0.13	0.0005 (−0.003, 0.004)	0.80	0.007 (−0.003, 0.02)	0.16

BMI = body mass index; F₂-IsoP = F₂-isoprostanes; NNRTI = non-nucleoside reverse transcriptase inhibitor; PI = protease inhibitor; PGE-M = prostaglandin E₂ metabolite; PGI-M = prostacyclin metabolite; RAL = raltegravir; TxB₂ = thromboxane B₂.