Splenic Stromal Cells from Aged Mice Produce Higher Levels of
IL-6 Compared to Young Mice

<table>IL-6 protein induced by LPS in CD45<sup>−</sup> or CD45<sup>+</sup> cells. Spleen-derived CD45<sup>−</sup> or CD45<sup>+</sup> cells from young and aged mice (<svg height="11.075" id="M13" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 36.237499 11.075" width="36.237499" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,-0,0,-.017,.062,10.8)"><path d="M495 86q-46 -47 -87 -72.5t-63 -25.5q-43 0 -16 107l49 210q7 34 8 50.5t-3 21t-13 4.5q-35 0 -109.5 -72.5t-115.5 -140.5q-21 -75 -38 -159q-50 -10 -76 -21l-6 8l84 340q8 35 -4 35q-17 0 -67 -46l-15 26q44 44 85.5 70.5t64.5 26.5q35 0 10 -103l-24 -98h2
q42 56 97 103.5t96 71.5q46 26 74 26q9 0 16 -2.5t14 -11.5t9.5 -24.5t-1 -44t-13.5 -68.5q-30 -117 -47 -200q-4 -19 -3.5 -25t6.5 -6q21 0 70 48z" id="x1D45B"></path></g><g transform="matrix(.017,-0,0,-.017,13.305,10.8)"><path d="M535 323h-483v50h483v-50zM535 138h-483v50h483v-50z" id="x3D"></path></g><g transform="matrix(.017,-0,0,-.017,28.008,10.8)"><path d="M456 178h-96v-72q0 -51 12.5 -62.5t72.5 -16.5v-27h-256v27q65 5 78 17t13 62v72h-260v28q182 271 300 426h40v-407h96v-47zM280 225v295h-2q-107 -148 -196 -295h198z" id="x34"></path></g>
</svg>) were cultured with 10 <i>μ</i>g/mL LPS for 24 h. Supernatants were collected from the cell culture and were analyzed for IL-6 by ELISA. The results are expressed as mean ± SD. The data are the representative of two similar experiments.</table>

Mediators of Inflammation

fig4

Figure 4

Figure 4: Splenic Stromal Cells from Aged Mice Produce Higher Levels of
IL-6 Compared to Young Mice 

Mediators of Inflammation

Splenic Stromal Cells from Aged Mice Produce Higher Levels of IL-6 Compared to Young Mice

Figure 4