Chitosan Oligosaccharides Attenuate Ocular Inflammation in Rats with Experimental Autoimmune Anterior Uveitis

Figure 3

Evaluation of the protein expression levels of inflammatory mediators at day 14 by western blot analysis. The protein levels of (a) TNF-α, (b) iNOS, (c) MCP-1, (d) RANTES, (e) fractalkine, and (f) ICAM-1 were significantly higher in the PBS-treated group compared with the normal rats. In the COS-treated groups, especially in the high-dose group, the levels of inflammatory mediators were significantly lower than in the PBS-treated group. The data are expressed as the mean ± SD (^∗𝑃<0.05 compared with the PBS-treated group; ^#𝑃<0.05 compared with the normal group; ^&𝑃<0.05 compared with the low-dose group by Kruskal-Wallis 𝐻 test with post hoc Dunn test; 𝑛=8 for each group).

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