IVS1 −397T>C Estrogen Receptor α Polymorphism Is Associated with Low-Grade Systemic Inflammatory Response in Type 1 Diabetic Girls
Figure 1
Serum levels of IL-6, TNF-α, VEGF, and IL-10 in DM1 girls differing in the IVS1 −397T>C polymorphism. In DM1 group the value of serum cytokines was measured by ELISA and analyzed according to different genetic variants of the IVS1 –397T>C estrogen receptor α polymorphism. (a) The mean value (25/75 percentiles) of IL-6 was 0.48 (0.03/1.5), 0.7 (0.3/1.84), and 1.39 (0.7/2.157) pg/mL for CC, CT, and TT, respectively. (b) The mean value (25/75 percentiles) of TNF-α was 0.6 (0.15/1), 1 (0.2/2), and 1.4 (0.5/2.4) pg/mL for CC, CT, and TT, respectively. (c) The mean value (25/75 percentiles) of VEGF was 76.89 (36.28/128.39), 128.45 (43.89/227.04), and 221.1 (57.4/382.76) pg/mL for CC, CT, and TT, respectively. (d) The mean value (25/75 percentiles) of IL-10 was 1.2 (0.3/2.2), 0.6 (0.0/1.7), and 0.5 (0.0/1.1) pg/mL for CC, CT, and TT, respectively. Differences were calculated by the Kruskal-Wallis ANOVA test and the post hoc NIR test.
