Cytomegalovirus Infection Impairs Immunosuppressive and Antimicrobial Effector Functions of Human Multipotent Mesenchymal Stromal Cells
Figure 1
CMV infection abrogates the immunosuppressive effect of human MSC. Peripheral blood lymphocytes (PBL; 1 × 105/well) were activated with a CD3-directed mAb (OKT3) and cultured in the presence or absence of MSC (2 × 104/well) which were infected with CMV (MOI 5) or not. After three days T-cell proliferation was assessed using [3H] thymidine incorporation. Data are displayed as mean cpm ± SD of a representative experiment performed in triplicate.
