Cytomegalovirus Infection Impairs Immunosuppressive and Antimicrobial Effector Functions of Human Multipotent Mesenchymal Stromal Cells
Figure 3
Dose dependency of MSC-mediated effects on T-cell proliferation. Different amounts of MSC ((a) 2 × 104/well and (b) 2 × 104 or 5 × 103/well), either CMV infected (MOI 5) or not, were cocultured with OKT3-activated PBL. Thereafter, T-cell proliferation was determined as described above. Data are given as % of positive control, that is, OKT3-activated PBL without MSC. Each dot represents a single data point from a total of 15 individual experiments, each performed in triplicate. A significant inhibition of T-cell proliferation by MSC is marked with asterisks.
