Intestinal Mucosal Barrier Is Injured by BMP2/4 via Activation of NF-B Signals after Ischemic Reperfusion

Figure 4

(a) BMP2 (100 ng/mL) significantly induced the expression of TNF-𝛼 mRNA. BMP2 combined with noggin partially reversed the increase in the TNF-𝛼 mRNA. (b) The effect of BMP4 in inducing the expression of TNF-𝛼 mRNA was weaker compared to BMP2, and the expression of TNF-𝛼 mRNA induced by BMP4 was also decreased by noggin. (c) and (d) BMP4 and BMP2 both increased the expression of IL-6 mRNA, and these effects were decreased by noggin. ^∗Different from the control after BMP2 and BMP4 treatment, ^∗∗𝑃<0.01, ^∗𝑃<0.05. ^#Different from a single treatment with BMP2 or BMP4, 𝑃<0.05. Data are representative of 3 similar experiments.

(a)

(b)

(c)

(d)