The Functional Polymorphisms of miR-146a Are Associated with Susceptibility to Severe Sepsis in the Chinese Population

Table 1

Clinical characteristics of sepsis cases and healthy controls.

Characteristics	Cases (𝑛=226)	Controls (𝑛=206)	𝑃 value
	𝑁 (%)	𝑁 (%)
Age (years)	61.61±15.59	59.87±10.66	0.174
Male/female, 𝑛	153/73	140/66	0.954
Organ dysfunction
One, 𝑛 (%)	37 (16.4)	N.A
Two, 𝑛 (%)	72 (31.9)	N.A
Three or above, 𝑛 (%)	83 (36.7)	N.A
Sepsis status
Sepsis, 𝑛 (%)	34 (15.0)	N.A
Septic shock, 𝑛 (%)	65 (28.8)	N.A
Severe sepsis, 𝑛 (%)	127 (56.2)	N.A
Source of infection, 𝑛 (%)
Respiratory tract infection	181 (80.1)	N.A
Primary bloodstream infection	90 (39.8)	N.A
Wound infection	23 (10.2)	N.A
Abdominal infection	84 (37.2)	N.A
Urinary tract infection	7 (3.1)	N.A
Catheter-associated infection	31 (13.7)	N.A
Others	22 (9.7)	N.A
Pathogens, 𝑛 (%) (positive blood cultures)
Gram-negative	82 (36.3)	N.A
Gram-positive	40 (17.7)	N.A
Mixed Gram-negative and -positive	78 (34.5)	N.A
Fungus	47 (20.8)	N.A
Negative blood cultures	12 (5.3)	N.A
APACHE II score	20.5±5.9	N.A
28-day mortality, 𝑛 (%)	97 (42.9)	N.A

N.A: not applicable; APACHE II: Acute Physiology and Chronic Health Evaluation II.