The Functional Polymorphisms of miR-146a Are Associated with Susceptibility to Severe Sepsis in the Chinese Population
Table 2
Genotype and allele frequencies distribution in patients with sepsis and controls.
Genotype
All sepsis cases, (%)
Controls, (%)
value
value*
OR (95% CI)
rs2910164
Total
226
206
0.047
0.063
CC
88 (38.94)
101 (49.03)
GC
114 (50.44)
93 (45.15)
GG
24 (10.62)
12 (5.82)
GG/GC
138 (61.06)
105 (50.97)
0.035
0.063
1.508 (1.029–2.211)
GC/CC
202 (89.38)
194 (94.18)
0.072
0.072
0.521 (0.253–1.070)
Allele
C allele
290 (64.16)
295 (71.60)
1.000 (reference)
G allele
162 (35.84)
117 (28.40)
0.019
0.063
1.408 (1.056–1.878)
rs57095329
Total
222
205
0.818
0.830
AA
144 (64.86)
135 (65.85)
GA
69 (31.08)
64 (31.22)
GG
9 (4.05)
6 (2.93)
GG/GA
78 (35.14)
70 (34.15)
0.830
0.830
1.045 (0.701–1.557)
GA/AA
213 (95.95)
199 (97.07)
0.527
0.830
0.714 (0.249–2.042)
Allele
A allele
357 (80.41)
334 (81.46)
1.000 (reference)
G allele
87 (19.59)
76 (18.54)
0.694
0.830
1.071 (0.761–1.508)
OR: odds ratio; 95% CI: 95% confidence interval; *false discovery rate-adjusted value for multiple hypotheses testing using the Benjamini-Hochberg method.
