The Functional Polymorphisms of miR-146a Are Associated with Susceptibility to Severe Sepsis in the Chinese Population

Table 4

Genotype and allele frequencies distribution in surviving and nonsurviving patients.

Genotype	Survivors 𝑁 (%)	Nonsurvivors 𝑁 (%)	𝑃 value	𝑃 value*	OR (95% CI)
rs2910164
Total	129	97	0.148	0.296
CC	48 (37.21)	40 (41.24)
GC	71 (55.04)	43 (44.33)
GG	10 (7.75)	14 (14.43)
Allele
C	167 (64.73)	123 (63.40)			1.000 (reference)
G	91 (35.27)	71 (36.60)	0.771	0.771	0.944 (0.640–1.392)
rs57095329
Total	125	97	0.015	0.030
AA	90 (72.00)	54 (55.67)
GA	29 (23.20)	40 (41.23)
GG	6 (4.80)	3 (3.10)
Allele
A	209 (83.60)	148 (76.29)			1.000 (reference)
G	41 (16.40)	46 (23.71)	0.054	0.054	0.631 (0.394–1.011)

OR: odds ratio; 95% CI: 95% confidence interval; *False discovery rate-adjusted 𝑃 value for multiple hypotheses testing using the Benjamini-Hochberg method.