Antagonizing Arachidonic Acid-Derived Eicosanoids Reduces Inflammatory Th17 and Th1 Cell-Mediated Inflammation and Colitis Severity

Figure 4

Percentage of splenic CD4⁺ T cell subsets in Wt and Fat-1 TNBS-treated mice (black bars, 𝑛=10–12 spleens/genotype) and saline controls (grey bars, 𝑛=4/genotype). (a) Th17 cells (CD4⁺ IL-17A⁺), (b) Th1 cells (CD4⁺ IFNγ ⁺), (c) Th2 cells (CD4⁺ IL-4⁺), and (d) Tregs (CD4⁺ Foxp3⁺). Data were analyzed by two-way ANOVA (main effects: genotype and treatment). Bars represent means ± SEM. Bars not sharing a symbol differ (𝑃≤0.05).

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